Óscar Murillo

Murillo began his career in the youth system of famed Argentinian side Boca Juniors. In 2007, he returned to Colombia to play for second division side Centauros Villavicencio. In 2008, he joined his hometown side Deportes Quindío and became a regular starter. His play with Quindío led to interest from foreign sides, particularly from Major League Soccer. He was signed on loan by Colorado Rapids in February 2010. His loan was terminated in July 2010 without Murillo making a single league appearance. On 20 February 2012, he played for Atlético Nacional and scored twice in their win against Millonarios FC.

Pachuca

On 10 December 2015, Pachuca announced that Murillo would be joining the team for the Clausura 2016.

In May 2018 he was named in Colombia's preliminary 35 man squad for the 2018 World Cup in Russia.

International

As of match played 9 September 2021

Atlético Nacional

Categoría Primera A (3): 2013-I, 2013-II, 2014-I Copa Colombia (2): 2012, 2013 Superliga Colombiana (1): 2012 Pachuca

Liga MX (2): Clausura 2016, Apertura 2022 CONCACAF Champions League (1): 2016–17 Colombia

Copa América third place: 2021