Santiago Cáseres

Vélez Sarsfield

Cáseres made his professional debut for Vélez Sarsfield entering the field in a 0–3 defeat to Newell's Old Boys, for the 2016–17 Argentine Primera División. The team's coach at the time was Omar De Felippe. The midfielder became a regular starter for Vélez during the 2017–18 Argentine Primera División. Due to his strong performances, at the end of the first semester of the season Cáseres was linked with a possible move to Atlético Madrid, reportedly willing to pay his buyout clause of US$12 million.

Villarreal

Cáseres signed a five-year contract with Villarreal CF on 16 July 2018.

Club América

On 29 January 2020, Cáseres joined Liga MX side Club América on a one-year loan agreement up to 31 December 2020, with the option for a permanent deal.

Vélez Sarfield

On 22 February 2021, Cáseres returned to Argentina to Primera División side Vélez Sarfield, on a loan deal until December 2021. After that, in 2022 Cáseres signed a contract with Vélez Sarfield until December 2024 for $2.36 million.

Club

As of 29 November 2020

Vélez Sarsfield

Argentine Primera División: 2024