Daniel Vega

Arriving from Nueva Chicago for the 2007–08 season he is at the start of the season considered to be River's fourth-choice keeper after the unexpected return of Juan Pablo Carrizo. Vega was part of the River Plate squad that won the Clausura 2008 tournament, but he did not play in any of the games.

Anorthosis Famagusta

On 2 September 2013, Anorthosis Famagusta announced the contract agreement with Mario Vega. In November 2013, Vega assumed the role of starting goalkeeper following an injury to Anorthosis Famagusta's starting keeper Mathieu Valverde.

Miami FC

In September 2016, Vega signed with Miami FC of the North American Soccer League. Vega played in 64 regular season games for Miami from 2016 to 2017. After the dissolution of the NASL, Vega stayed with the team as they played as Miami FC 2 in the National Premier Soccer League, winning the 2018 NPSL championship in August.

Tampa Bay Rowdies

Following the conclusion of the National Premier Soccer League season, Vega signed with the Tampa Bay Rowdies for the remainder of their United Soccer League season.

San Jose Earthquakes

On 18 January 2019, Vega signed with Major League Soccer's San Jose Earthquakes. Following the 2021 season, Vega's contract with San Jose expired.