Flavio Roma

Roma started his career in the youth teams of Lazio. He was the third goalkeeper behind Luca Marchegiani and Fernando Orsi before leaving the club to play for clubs in Serie B and Serie C1. In 1999, he was signed by the Serie A side Piacenza as part of Simone Inzaghi's deal, replacing Valerio Fiori as the first choice in his role. Still, the team was relegated at the end of the season.

Monaco

In 2001, he was signed by Monaco, then coached by Didier Deschamps, where he was the first-choice goalkeeper ahead of Tony Sylva and Stéphane Porato until the 2008–09 season, when he lost his place to Stéphane Ruffier. He was also in the squad that played the 2004 UEFA Champions League final. During his stay at Monaco, he only missed three months in the 2005–06 season due to injuries, and a shoulder injury ruled him out of the second half of the 2001–02 season in February 2002. During his career at Monaco, Roma rejected an opportunity to join English side Arsenal in order to sign a new contract with the club.

Milan

On 12 August 2009, Roma signed a one-year contract with Milan to replace Zeljko Kalac, who was released from the club by mutual consent. Upon joining Milan, Roma cited joining the club as a dream come true, and Roma was expected to compete for the starting position with Marco Storari while Christian Abbiati and Dida were recovering from injury. However, Milan manager Leonardo preferred Storari and, after his return from injury, Dida. In January 2010,…

Roma received his first call-up for Italy ahead of Italy's friendly match against Finland, in Messina, on 17 November 2004, as manager Marcello Lippi was trying to identify a back-up goalkeeper for Gianluigi Buffon for the 2006 World Cup qualifying cycle; Roma did not appear in the match, however, which ended in a 1–0 victory to the Italians. Roma made his debut on 30 March 2005 in a 0–0 friendly draw with Iceland after replacing Morgan De Sanctis at half-time. That same year, he played his first full match as a starter on 11 June, in a friendly against Ecuador in the United states, which ended in a 1–1 draw. Later that year, he also appeared in Italy's 2–1 friendly defeat to Ireland in Dublin, on 17 August. Due to Roma's injury struggles throughout the 2005–06 season, he was not called up for Italy's warm-up friendlies ahead of the 2006 FIFA World Cup, and was not included in the final squad for the tournament, with Buffon, Angelo Peruzzi, and Marco Amelia being selected as the team's three goalkeepers, and De Sanctis as a reserve. Roma received his last senior international call-up in August 2006 under new manager Roberto Donadoni, ahead of Italy's first match after their 2006 World Cup victory, with Amelia starting ahead of him in the 2–0 friendly defeat to Croatia in Livorno, on 16 August. Roma did not make any more appearances for his country; in total, he received three caps for Italy, all in 2005.

Roma was known for his reflexes and shot-stopping ability as a goalkeeper. According to former Milan and Italy goalkeeper Giovanni Galli, Roma had excellent physical and mental attributes, as well as good goalkeeping technique, and a strong, dedicated, serious, and hard-working character. He likened Roma's style to that of his compatriot Francesco Toldo, even describing him as a potential successor for Toldo at Fiorentina. He highlighted Roma's ability to get to ground quickly, in spite of his large stature, as one of his main qualities, while he cited Roma's consistency and concentration as areas in need of improvement his youth.

After retirement, Roma was hired by his former club AS Monaco as a goalkeeping coach for the youth teams, a role he filled in between 2017 and 2020. In 2022, Roma was named new goalkeeping coach of AC Milan, replacing Dida. He left AC Milan after just a year, as the club opted not to extend his contract.