Francesco Ardizzone

Born in Palermo, Sicily, Ardizzone started his professional career at U.S. Città di Palermo. He was a member of the reserve from 2009 to 2011. Ardizzone made his debut in the last group stage match of 2010–11 UEFA Europa League on 15 December 2010.

Reggiana

On 1 July 2011, Ardizzone left for Italian third division club Reggiana along with Adriano Siragusa, as part of the deal that Gianluca Di Chiara moved to Palermo. Both clubs retained 50% registration rights of Ardizzone and Di Chiara. Half of the "card" of Di Chiara was valued for €140,000 at that time. Ardizzone made 21 appearances in 2011–12 Lega Pro Prima Divisione. In June 2012, Reggiana acquired Ardizzone outright.

Pro Vercelli

On 29 August 2013, Ardizzone was sold to F.C. Pro Vercelli 1892 in another co-ownership deal for a peppercorn of €500. In June 2014 the co-ownership of Ardizzone and Mattia Bani were renewed.

Cesena

On 17 January 2020, he signed a 1.5-year contract with Serie C club Cesena.

Turris

On 19 July 2022, Ardizzone moved to Turris on a three-year contract.

Lecco

On 10 January 2023, Ardizzone was loaned by Lecco. The signing was made permanent in the summer of 2023, however, Ardizzone made no appearances for Lecco in the first half of the 2023–24 season after Lecco was promoted to Serie B. On 1 February 2024, Ardizzone was loaned by Monopoli.

Taranto

On 29 August 2024, Ardizzone signed a one-year contract with Taranto.

Ardizzone was capped 3 times in friendlies and 2 times in 2011 UEFA European Under-19 Football Championship elite qualification for Azzurrini in the 2010–11 season. In the 2011–12 season, he was promoted to Italy U20 team. He played 3 times in 2011–12 Four Nations Tournament and two additional friendlies against Macedonia and Denmark.

On 29 January 2021 he tested positive for COVID-19.