Mario de Luna

C.D. Guadalajara

A product of Chivas youth team, CD Tapatio, de Luna made his professional debut on November 9, 2008, against Puebla F.C. in the 2008 Apertura. At the 2009 Interliga de Luna replaced the injured Jonny Magallón performing brilliantly in the tournament, although he suffered an injury in the final. On September 6, 2009, he scored his first goal in the Primera División de México helping Chivas to a 2–2 draw against Puebla.

CD Chivas USA

On February 21, 2013, sister club Chivas USA announced they had acquired Mario de Luna and teammates Giovani Casillas and Edgar Mejia on loan from CD Guadalajara. After pushing and verbally abusing a ball boy during a game against the Portland Timbers on May 12, 2013, de Luna earned a yellow card for "Foul and abusive language" directed towards a child.

Necaxa

Copa MX: Clausura 2018