Pelly Ruddock

Early career

Born in Hendon, Greater London, Mpanzu began his career with the youth system at Boreham Wood and made 13 first-team appearances.

West Ham United

Mpanzu signed a two-and-a-half-year professional contract with Championship club West Ham United on 5 December 2011 after a successful trial. He was a member of the West Ham team which won the Ciutat de Barcelona Trophy against Espanyol in September 2013. Mpanzu made his first-team debut in a 2–0 win away to Burnley in the League Cup fourth round on 29 October 2013. West Ham manager Sam Allardyce said of his debut, "This was their big chance. Three players, all defenders, Pelly Ruddock Mpanzu, Dan Potts and Leo Chambers, can feel very proud of themselves, what they've done."

Luton Town

On 28 November 2013, Mpanzu signed for Conference Premier club Luton Town on loan until 4 January 2014. He made his Luton debut in central defence two days later in a 0–0 draw with Staines Town in the FA Trophy, and was named man of the match in the replay, which Luton won 2–0, while playing in central midfield. He played in central midfield for five further matches, all victories, before being recalled to West Ham's squad on 30 December due to his parent club's injury crisis. After impressing in his seven matches for Luton, manager John Still revealed that he was looking to bring Mpanzu back to Kenilworth Road. On 28 January 2014, Mpanzu signed for Luton permanently on a two-and-a-half-year contract for an…

Born in England, Mpanzu is of Congolese descent. He was called up to represent the DR Congo national team for a pair of friendlies in June 2021. He debuted with the DR Congo in a 1–0 friendly loss to Tunisia on 5 June 2021.

Mpanzu has been described as a "powerful" box-to-box midfielder with "endless energy". Mpanzu has stated that central midfield is his natural position, but that he is able to play as a centre-back.

His cousin Peter Kioso is also a footballer; the two played together at Luton Town.