Simone Muratore

Juventus

During the 2016–17 and 2017–18 seasons, Muratore received a call-up for the Juventus senior side in both the Coppa Italia and the UEFA Champions League respectively but did not appear on the pitch on either occasion, remaining on the bench. He made his Serie C debut for Juventus U23 on 16 September 2018 in a 2–1 home defeat against Alessandria. On 11 December 2019 he made his Champions League debut with Juventus in the team's final group match, a 2–0 away win over Bayer Leverkusen. On 26 June 2019, he made his Serie A debut, appearing as a second-half substitute in Juventus's 4–0 home win over Lecce. On 24 June 2020, it was announced that Muratore had been sold to Atalanta.

Atalanta

On 29 June 2020, Muratore signed for Atalanta for a fee of 7 million euros. On 31 August 2021, he joined Tondela in Portugal on loan. He left Atalanta by the end of his contract on 30 June 2023.

On 13 October 2020, he made his debut with the Italy U21 playing as a starter in a qualifying match won 2–0 against Republic of Ireland in Pisa.

In December 2024, Juventus announced the appointment of Muratore as a new youth team collaborator following his retirement from active football.

In late 2021, Muratore was diagnosed with a benign brain tumor and underwent surgery to remove it; the illness forced him to stop his football career for two years.