Yerson

Early career

Raised in Nueva Colonia within the municipality of Turbo in Colombia's Antioquia Department, Mosquera began his journey in football at the Fundación Elkin Murillo Amor (later renamed for Nayo Murillo after being taken over by Jhon Jairo Murillo) founded by his uncle Elkin Murillo, before joining Urabá Junior and later returning to his uncle's amateur club, Filandia Fútbol Club. Although now a defender, he was deployed as both a forward and winger as a young child, playing as a defensive midfielder at the age of 11 before moving to centre-back. He joined the youth setup of Atlético Nacional in 2018, having been identified by a club scout during the 2018 Torneo de las Américas in Cali while playing for Filandia, and after successes with youth teams in 2018 and 2019, made his debut for the first team in the January 2020 edition of the Florida Cup. Mosquera made his professional debut for the club in October, where despite being sent off in a Copa Sudamericana game against River Plate, his impressive performance was rewarded with his continued integration in Nacional's first-team squad in the following months, and he scored his first professional goal in a 3–2 away win against Alianza Petrolera on 11 November.

Wolverhampton Wanderers

On 17 June 2021, Mosquera joined Premier League side Wolverhampton Wanderers on a five-year deal, having been on the verge of signing for Club Brugge. After sustaining an injury in pre season, Mosquera would make his…

Mosquera is a Colombian youth international was called up to train with the senior squad in February 2021. He was called up to play with the Colombian under-18 team in the 2019 SBS Cup, and was a starter in two of three matches during a championship-winning run. He earned his first call-up to the under-20s in October 2019, and having scored one goal in two appearances with the under-20s in December 2020, is also expected to be called up for the 2021 South American U-20 Championship. On 12 October 2023, he made his international debut for Colombia in a 2–2 draw against Uruguay, coming on in the 90th minute for Santiago Arias. On 10 September 2024, Mosquera scored his first international goal against Argentina, which led to a 2–1 win for La Sele.

Mosquera is considered a strong, quick defender, as well as a "complete" centre-back endowed with great aerial ability, which allows him to win the vast majority of his defensive duels. He is highly involved in most of his team's defensive actions, and is comparable to Rúben Dias on the ball and Wesley Fofana out of possession, with long passing ability and physical attributes similar to fellow Colombian centre-back Yerry Mina and pace and acceleration akin to that of Davinson Sánchez.

Mosquera is the nephew of former Colombia national team striker Elkin Murillo, whose club he played for as a child. Nicknamed "Ye" as a child and at Urabá, and "Yerri" at Atlético Nacional, Mosquera is one of ten siblings in his family (including a foster brother). His father, Jesús Adán Mosquera, is a banana plantation worker, while his maternal great uncle Agustín Julio was a Colombia national team goalkeeper. Two of his cousins, Daniel Valdelamar and Gustavo Cañizalez, also had short-lived careers within the Colombian top-flight.