Enock Mwepu

Early career

Mwepu's career began with Kafue Celtic in Lusaka before being identified with the 2013 Airtel Rising Stars. During the 2015–16 season, Mwepu had little game time with Power Dynamos football club of Copperbelt; this precipitated into a move to NAPSA Stars at the end of the 2017 season.

Red Bull Salzburg and loan to FC Liefering

In June 2017, Mwepu joined Red Bull Salzburg and was loaned out to Salzburg's feeder club FC Liefering who play in Austrian Football First League. During the 2019–20 season, Mwepu established himself amongst Salzburg's starting eleven. He made his debut in the UEFA Champions League during a 4–3 loss to Liverpool at Anfield. On 18 December 2019, Mwepu extended his contract with Salzburg until summer 2024.

Brighton & Hove Albion

On 6 July 2021, he joined Premier League side Brighton & Hove Albion on a four-year contract, for an undisclosed fee. He scored in a 3–1 pre-season friendly win at Luton Town on 31 July. He made his competitive debut on 14 August in the opening game of the 2021–22 season away at Burnley where he was replaced by Adam Lallana at half time of the 2–1 victory at Turf Moor. On 24 August, Mwepu assisted Jakub Moder's first Albion goal in the second round EFL Cup away fixture at Cardiff City where Albion won 2–0. He scored his first goal for Brighton on 27 October, putting them back level to 2–2 before a penalty shootout loss – in which his penalty was saved – away at Leicester City in the EFL…

In 2014 Mwepu was part of the Zambia national under-17 team that represented the country at the 2015 African U-17 Championship, where Zambia played Niger, Nigeria and Guinea from group A. Mwepu is known for his versatility in the field of play as demonstrated at the 2017 Under-20 Africa Cup of Nations in Zambia, where he scored a goal and was among the best substitutes of the tournament. Mwepu scored his first international goal for Zambia in an AFCON Qualifier against Algeria on 2 September 2017 at the National Heroes Stadium in Lusaka, a match which Zambia won 3–1.

After retiring from professional football due to his heart condition, Brighton announced on 30 December that Mwepu had been appointed to serve in the role of under-9s coach in their academy from January 2023.

His younger brother Francisco Mwepu is also a professional footballer for Cadiz CF. In January 2023, it was confirmed that Mwepu was in hospital in Zambia after a suspected heart attack, coming just a few months after being forced to retire from football due to a hereditary heart condition. Brighton announced he was receiving precautionary checks as a result.