Luis Manuel Orejuela

Deportivo Cali

Born in Cali, Orejuela represented Deportivo Cali as a youth. He made his first team debut on 7 August 2013 at the age of 18, starting in a 1–1 Copa Colombia away draw against Unión Magdalena. Orejuela made his Categoría Primera A debut on 5 April 2014, playing the full 90 minutes in a 1–0 away loss against Millonarios. Initially a backup option, he became a regular starter for the club from the 2016 season onwards; he scored his first senior goal on 20 November of that year, netting the opener in a 3–1 away defeat of Rionegro Águilas.

Ajax

On 11 August 2017, Orejuela moved abroad and signed a five-year contract with Eredivisie side Ajax. Initially assigned to the reserves in Eerste Divisie, he made his first team debut on 20 September, starting in a 5–1 away routing of SVV Scheveningen for the KNVB Cup. Orejuela made his debut in the Eredivisie on 17 December 2017, coming on as a half-time substitute for Deyovaisio Zeefuik in a 2–1 away win over AZ Alkmaar.

Cruzeiro

On 8 January 2019, Orejuela joined Cruzeiro on loan until December. Initially a backup to Edílson, he became a regular starter as his side suffered relegation for the first time in the club's history. At the end of the year, Cruzeiro exercised their option to sign Orejuela, paying $1.5 million for 50% of his rights.

Grêmio (loan)

On 17 January 2020, Orejuela joined Grêmio on loan.

São Paulo

On 11 March 2021, Orejuela signed with São Paulo.

Orejuela represented Colombia at under-20 level before receiving a call up to the full side on 13 March 2019, for two friendlies against Japan and South Korea. He made his full international debut on 26 March, starting in a 2–1 loss against the latter.

Club

As of 16 September 2020.

International

As of 17 December 2019

Deportivo Cali Categoría Primera A: 2015 Apertura Superliga Colombiana: 2014 Jong Ajax Eerste Divisie: 2017–18 Cruzeiro Campeonato Mineiro: 2019 Grêmio Campeonato Gaúcho: 2020 São Paulo Campeonato Paulista: 2021 Copa do Brasil: 2023