Mateo Musacchio

A press release of AC Milan described Musacchio as a "very physical centre back" with character and agility. Additionally, the article highlighted his marking and blocking abilities, and that he liked to start moves and play short passes."

Musacchio was first called by the Argentina national team in May 2011, as manager Sergio Batista only selected players under 25 for friendlies with Nigeria and Poland. He made his debut against the former on 2 June, in a 4–1 defeat. In 2017, Gianni De Biasi asked Musacchio if he would be interested in playing for Albania of which he was the manager, but the player declined as he wished to represent his country of birth.

River Plate

A product of Club Atlético River Plate's youth system, Musacchio was born in Rosario, Santa Fe, and he made his first-team debut as a 16-year-old during the 2006–07 season, making four appearances. He was part of the squad that won the Clausura the following year, but did not feature in any games.

Villarreal

In August 2009, Musacchio moved to Villarreal CF in Spain, initially being assigned to the B team in the Segunda División. He made his official debut on 5 September in a 3–1 away loss against Córdoba CF as the reserves overachieved in their first season ever in that tier, eventually finishing seventh. On 13 February 2010, shortly after ceasing to be a non-EU player, Musacchio made his La Liga debut by playing the last 15 minutes in a 2–1 home win over Athletic Bilbao. From that moment onwards he was permanently promoted to Villarreal's first team, successively surpassing more experienced Iván Marcano and Gonzalo Rodríguez – the latter his compatriot – in the defensive pecking order. Musacchio dealt with several injury problems during his spell at the Estadio El Madrigal.

AC Milan

On 30 May 2017, eight days after passing his medical, Musacchio moved to Italian club AC Milan after signing a four-year contract. He contributed 15 Serie A appearances in his first season, with the subsequent qualification for the UEFA Europa League after a sixth-place finish. Following Leonardo Bonucci's departure to Juventus FC and Mattia Caldara's two…

Musacchio's paternal grandparents were of Albanian origin, from Portocannone in lower Molise region, Italy. The surname Musacchio originated from the Muzaka region in south-central Albania, and was widely used in the country's community in Italy.