Sara Holmgaard

First spell at Fortuna Hjørring

On 28 June 2017, Holmgaard and her sister Karen signed for Fortuna Hjørring. She made her league debut against Varde on 14 August 2017. Holmgaard scored her first league goal against Varde on 14 October 2017, scoring in the 35th minute. On 22 May 2018, Holmgaard and Karen's contract was extended.

Turbine Potsdam

On 4 December 2020, she joined Turbine Potsdam, together with Karen Holmgaard. She made her league debut against Wolfsburg on 5 February 2021. Holmgaard scored her first league goal against SGS Essen on 6 June 2021, scoring in the 48th minute.

Everton

On 13 January 2023, Holmgaard returned to Everton. She made her league debut against Reading on 15 January 2023. Holmgaard scored her first league goal against Tottenham Hotspur on 4 May 2024. On 31 July 2024, Holmgaard signed a new contract with Everton. In the 2024–25 FA Cup fifth round against Chelsea, Holmgaard scored an Olimpico.

Loan to Fortuna Hjørring

Holmgaard made her league debut against Sundby on 6 August 2022. She scored her first league goal against AGF on 13 August 2022, scoring in the 8th minute.

Real Madrid

On 24 June 2025, Holmgaard joined Liga F club Real Madrid on a two-year deal.

She made her international debut for the Danish national team in the 2019 Algarve Cup, against Norway on 27 February 2019. She scored her first goal against Belgium on 12 July 2024, scoring in the 82nd minute. In June 2022, she was selected for A-national coach Lars Søndergaard's final squad at the European Championship 2022 in England.

She is the twin sister of Everton player Karen Holmgaard.

Fortuna Hjørring

Elitedivisionen Winner (1): 2017–18 Silver Medalist (1): 2018–19 Danish Women's Cup Winner (1): 2019