Isaac Cofie

Genoa

Cofie made his Serie A debut for Genoa C.F.C. on 2 May 2010, when he came on as a substitute in the 64th minute for Alberto Zapater in a game against A.S. Bari.

Torino (loan)

Cofie joined Torino on loan in the 2010–11 Serie B season.

Piacenza (loan)

On 4 January 2011, Cofie's loan to Torino from Genoa CFC was pre-matured. Cofie played for Piacenza until the end of the 2010–11 Serie B season.

Sassuolo (loan)

Cofie then joined Sassuolo on loan for the 2011–12 Serie B season, where he helped Sassuolo to reach the 2011–12 Serie B promotion play-offs, but they lost 3–2 on aggregate to UC Sampdoria over a two-legged tie.

Chievo

In July 2012, Cofie signed a contract with Serie A club Chievo Verona in co-ownership deal, for €1.5 million transfer fee. On 6 January 2013, he scored his first goal for Chievo against Atalanta (Serie A round 19). in June 2013 Genoa bought back Cofie for €5 million, in cash plus player deal (€1.5M cash plus Dejan Lazarević)

Return to Genoa

Cofie played 17 games in 2013–14 Serie A season for Genoa.

Return to Cheivo

On 28 August 2014, Cofie was signed by A.C. Chievo Verona in a temporary deal.

Sporting Gijón

On 7 August 2018, Cofie moved to Spain for signing a two-year contract with Segunda División team Sporting de Gijón.

Sivasspor

In July 2019, he moved to Turkish side Sivasspor. On 2 July 2021, Cofie signed a two-year contract extension with the club.

Cofie made his debut with the Ghana national team on 8 September 2012.

Sivasspor

Turkish Cup: 2021–22