Michele Di Gregorio

Inter Milan

Born in Milan, Italy, Di Gregorio was a youth product of Inter Milan.

Loan to Renate

On 12 July 2017, Di Gregorio and Alessandro Mattioli were signed by Serie C side Renate on a season-long loan deal. On 30 July he made his debut for Renate in the first round of Coppa Italia in a 3–1 home win over Siracusa. On 3 September, Di Gregorio made his Serie C debut for Renate and he kept his first clean sheet in a 3–0 home win over Padova. One week later he kept his second clean sheet in a 1–0 away win over FeralpiSalò. On 16 September, Di Gregorio kept his third clean sheet in a 3–0 away win over Modena. On 17 December, Di Gregorio kept his 10th clean sheet in a 1–0 home win over Pordenone. Di Gregorio ended his season-long loan to Renate with 38 appearances, 14 clean sheets, and 36 goals conceded.

Loan to Novara

On 4 July 2018, it was announced that Di Gregorio was loaned to a Serie B club Avellino. However, he did not play any matches for the team and returned to Inter Milan. On 24 August 2018 he was loaned to Novara. On 30 September he made his Serie C debut for Novara in a 1–1 home draw against Juventus U23. On 7 October he kept his first clean sheet for Novara in a 3–0 away win over Piacenza. Three week later he kept his second clean sheet in a 2–0 away win over Pistoiese. On 18 November he kept his third clean sheet in a 0–0 away draw against Cuneo. On 12 December he was sent-off with a red card in the 90th minute of a 1–1 away draw…

On 19 February 2014, Di Gregorio made his Italy under-17 debut as a substitute, replacing Emil Audero in the 59th minute of a 6–0 home win over Hungary U17. In October 2024, he was selected for the senior Italy squad for 2024–25 UEFA Nations League matches against Belgium and Israel on 10 and 14 October 2024, respectively.

During his time at Monza, Di Gregorio established himself as one of the best goalkeepers in Italy, standing out for his shot-stopping ability, his ability to keep clean sheets while producing many saves, stop penalties, and distribute the ball effectively and launch attacks; he was named the Serie A Best Goalkeeper of the 2023–24 season for his performances, and drew praise from former Juventus and Italy goalkeeper Gianluigi Buffon, even being touted as a potential successor to him at the Turin-based side. Upon signing with Juventus, his club profile described him as an "all-round goalkeeper," with a "modern" style, who possessed good reflexes and shot-stopping abilities, in addition to being adept at playing with his feet. During the latter half of his second season at the club, however, he suffered a decline in form, which led his shot-stopping ability to be brought into question by several pundits, in particular following a series of poor performances in Serie A and the Coppa Italia, which led him to be dropped from the starting line-up in favour of Mattia Perin.

Di Gregorio is affectionately nicknamed "L'Uomo Digre", a play on words in reference to television anime Tiger Mask (L'Uomo Tigre in Italian). He and his partner Samantha have a son named Marcello (b. 2020).